Why is SYRE Down Today?

SYRE
$103.84
▼ -2.79% ($-2.90)
Last updated: Nov 12, 2026 8:30 PM ET (488 min ago)

About Spyre Therapeutics, Inc. Common Stock

Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characteriz...

Sector: PHARMACEUTICAL PREPARATIONS
Market Cap: $994.20M
Forward P/E: -9.0
52-Week Range: $22.13 - $110.64
Employees: 65

Overall Confidence: 50%

50% Confident

Based on news, social sentiment, options activity, and sector analysis

MOMENTUM 50% Confidence
🎯 SYRE showing strong bearish momentum
SYRE is down 2.8% today on 0.4x average volume. The move appears to be driven by general market sentiment and momentum traders.

✅ Move Confirmation

LOW VOLUME 0.4x average volume

UNCONFIRMED - Low volume suggests this move may not be sustainable.

📍 Sector Context

PHARMACEUTICAL PREPARATIONS sector: -0.6%

SYRE is outperforming its sector by -2.2%. This suggests a stock-specific catalyst.

Market Comparison

SYRE is significantly underperforming the market (-2.4% vs SPY)
S&P 500
SPY
-0.35%
Nasdaq 100
QQQ
-0.32%
SYRE
This Stock
-2.79%
vs S&P 500: -2.44%
vs Nasdaq: -2.47%

📊 What Happens Next?

Probability Analysis

45% chance this move continues in the next 1-3 days

Expected Range

Based on historical patterns and options pricing, SYRE is expected to trade between:
$100.72 - $105.91

Key Level to Watch

$98.64 support
Watch for breakdown below $103.83

🔔 Get SYRE Alerts

We'll notify you when SYRE's trend changes or a new signal fires.

Last updated: Nov 12, 2026 8:30 PM (488 minutes ago)
Data refreshes every 30 minutes during market hours

Historical Context

SYRE has moved more than 3.0% down on 34 occasions in the past year.

41.2%
Continuation Rate
14/34 times continued down
+1.16%
Avg Next Day Change
After similar down moves
Last similar move: Nov 10, 2026 (-4.1%) → Next day: +2.2%

Frequently Asked Questions

Why is SYRE stock down today?

SYRE is down 2.8% today on 0.4x average volume. The move appears to be driven by general market sentiment and momentum traders.

Is SYRE stock a buy or sell right now?

Based on current analysis, SYRE shows 50% confidence in today's move. Volume is low which does not confirm the trend. View full buy/sell analysis →

What is the SYRE stock price target?

SYRE is currently trading at $103.84. Based on today's momentum, the expected short-term range is $100.72 - $105.91. See long-term price prediction →

Will SYRE stock continue falling?

Our analysis shows a 45% probability that SYRE's move continues in the next 1-3 days. Key level to watch: $98.64 (support).

Is SYRE stock oversold or overbought?

SYRE's RSI (Relative Strength Index) is currently at 58.2. This shows bullish momentum - the stock has positive momentum but isn't overextended yet.

What is the momentum for SYRE stock?

SYRE's 10-day momentum indicator is at 3.95. Strong bullish momentum - the stock is gaining significant upward force. This often precedes continued gains.

Is SYRE outperforming or underperforming the market?

SYRE (-2.79%) is currently significantly underperforming the market (-2.4% vs SPY). Today, the S&P 500 (SPY) is down -0.35%, and Nasdaq (QQQ) is down -0.32%.

What does MACD indicate for SYRE?

SYRE's MACD (4.19) is currently above the signal line (3.24), indicating a bullish trend. This technical signal suggests buying pressure is dominant. The trend strength (ADX: 19.1) is weak.

Is SYRE in an uptrend or downtrend?

Based on moving average analysis, SYRE is in a bullish trend. The price ($103.84) is trading above both the 20-day SMA ($96.82) and 50-day SMA ($91.15). This alignment typically indicates sustained upward momentum.

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