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IONS

Ionis Pharmaceuticals, Inc. Common Stock
Data: 2026-07-31
$51.77
Price
-2.83%
Change
$86.74
52W High
$40.03
52W Low
Full AI Analysis Buy/Sell Forecast Trendline Why Moving Charts Options

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.

Quick Stats
Jul 31, 2026

59.4

AI Score

HOLD

0.66

Volume Ratio

Jul 29, 2026

Next Earnings

12

+ve Days (30d)

18

-ve Days (30d)

IONS Stock Summary

Last updated Jul 31, 2026

IONS is currently trading at $51.77, positioned below its 200-day moving average of $75.18, suggesting bearish momentum. The stock has a 52-week range of $40.03 to $86.74.

Technical Analysis: The 50-day moving average stands at $69.45, which is above the current price, indicating bearish near-term pressure. The RSI (Relative Strength Index) reads 26.353, suggesting the stock is oversold and potentially undervalued.

Money Flow Indicators: The Chaikin Money Flow (20-day) is -0.294, which is negative, suggesting distribution or selling pressure. Our AI-powered investment score rates IONS at 59.4/100 with a HOLD recommendation.

IONS (Ionis Pharmaceuticals, Inc. Common Stock) Indicators

Last updated Jul 31, 2026

Indicator Value
RSI(14) 26.353
CMF (20) -0.294
ROC (10) -4.817
ADX (14) 39.618
Indicator Value
MACD (12,26,9) -5.293
AROONOSC (14) -50.0
WILLAMS %R (14) -76.388
MFI (14) 22.194
IONS Technical Chart
  • Candlesticks: Green = price up, Red = price down. Body shows open/close, wicks show high/low.
  • SMAs: Moving averages help identify trends. Price above SMA = bullish, below = bearish.
  • Options OI: Shows max open interest strikes. High OI = significant price levels.
  • Volume Profile: Shows price levels with most trading activity. POC = Point of Control (highest volume).
  • Earnings: Vertical lines mark earnings dates. Watch for volatility around these dates.
  • Gamma Walls: Key support/resistance from options gamma exposure. Orange = resistance above, Purple = support below.
  • Fibonacci Retracement: Auto-calculated support/resistance levels based on recent high/low. Key levels: 23.6%, 38.2%, 50%, 61.8%, 78.6%.
  • Unusual Activity: Highlights days with abnormal volume (2x+ average) or large price moves (5%+). Red marker = unusual activity detected.
Technical Indicators

Select indicators above to analyze technical patterns

Indicators will appear below the price chart with perfectly aligned dates

Volume Profile Analysis

Horizontal histogram showing volume distribution at each price level with buying/selling pressure

IONS Price vs Max Options Open Interest
IONS Max Change In Options Open Interest

IONS Options - Sort by Max open Interest (near term)

2nd August 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike OI Change in
OI		 Volume Ask PC Delta Vega Volatility % change Track

IONS Daily Out of Money Options - Sort by Max open Interest (near term)

2nd August 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike OI Change in
OI		 Volume Ask PC Delta Vega Volatility % change Track

IONS Daily In the Money Options - Sort by Max open Interest (near term)

2nd August 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike OI Change in
OI		 Volume Ask PC Delta Vega Volatility % change Track

IONS Most Active Options by Volume(near term)

2nd August 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike Volume OI Change in
OI		 Ask PC Delta Vega Volatility % change Track

Ionis Pharmaceuticals, Inc. Common Stock is below both the 50 Day and 200 Day SMA which is considered Bearish.

IONS Moving Averages Analysis

IONS (Ionis Pharmaceuticals, Inc. Common Stock) Simple Moving Averages

Moving Averages are last updated Jul 31, 2026

Days MA
10 54.31
20 59.75
30 65.94
50 69.45
100 71.82
200 75.18

IONS Fundamental Analysis

P/E (Forward) 90.9091
P/E (Trailing) --
Market Cap ($) 8.9 billion
Earnings/Share ($) -3.43
Net Profit Margin (%) -0.6471
Dividend/Share ($) --
EPS Estimate Current Year ($) -2.6525
EPS Estimate Next Year ($) -1.52
WallStreet Target Price ($) 90.80
Most Recent Quarter