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IONS

Ionis Pharmaceuticals, Inc. Common Stock
Data: 2026-09-11
$54.21
Price
-2.59%
Change
$86.74
52W High
$50.01
52W Low
Full AI Analysis Buy/Sell Forecast Trendline Why Moving Charts Options
Analyzing positioning… Options positioning — based on yesterday's biggest open-interest changes See the chart Institutional flows
Track record
signal day → next-day price move
Quick Stats
Sep 11, 2026

49.8

AI Score

HOLD

0.83

Volume Ratio

Nov 04, 2026

Next Earnings

14

+ve Days (30d)

16

-ve Days (30d)

IONS Price vs Max Options Open Interest

How to read this: the line is the stock price; the bars show where the most option open interest sits each day. Strikes with heavy open interest often act as magnets or barriers for price ("max pain" zones). Scroll right for the most recent days.

IONS Max Change In Options Open Interest

How to read this: each bar is the option contract whose open interest changed the most yesterday. Green bars = new positions being opened (conviction building at that strike); red bars = positions being closed. Call builds above the current price suggest upside bets; put builds below it suggest hedging or downside bets.

IONS Options - Sort by Max open Interest (near term)

12th September 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike OI Change in
OI		 Volume Ask PC Delta Vega Volatility % change Track

IONS Daily Out of Money Options - Sort by Max open Interest (near term)

12th September 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike OI Change in
OI		 Volume Ask PC Delta Vega Volatility % change Track

IONS Daily In the Money Options - Sort by Max open Interest (near term)

12th September 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike OI Change in
OI		 Volume Ask PC Delta Vega Volatility % change Track

IONS Most Active Options by Volume(near term)

12th September 2026 (Data is delayed in normal mkt. hours)

Type Expiration Strike Volume OI Change in
OI		 Ask PC Delta Vega Volatility % change Track
IONS Technical Chart
  • Candlesticks: Green = price up, Red = price down. Body shows open/close, wicks show high/low.
  • SMAs: Moving averages help identify trends. Price above SMA = bullish, below = bearish.
  • Options OI: Shows max open interest strikes. High OI = significant price levels.
  • Volume Profile: Shows price levels with most trading activity. POC = Point of Control (highest volume).
  • Earnings: Vertical lines mark earnings dates. Watch for volatility around these dates.
  • Gamma Walls: Key support/resistance from options gamma exposure. Orange = resistance above, Purple = support below.
  • Fibonacci Retracement: Auto-calculated support/resistance levels based on recent high/low. Key levels: 23.6%, 38.2%, 50%, 61.8%, 78.6%.
  • Unusual Activity: Highlights days with abnormal volume (2x+ average) or large price moves (5%+). Red marker = unusual activity detected.
Technical Indicators
Select an indicator above — it will be added as a pane under the price chart with aligned dates.

Volume Profile Analysis

Horizontal histogram showing volume distribution at each price level with buying/selling pressure

IONS Stock Summary

Last updated Sep 11, 2026

IONS is currently trading at $54.21, positioned below its 200-day moving average of $73.06, suggesting bearish momentum. The stock has a 52-week range of $50.005 to $86.74.

Technical Analysis: The 50-day moving average stands at $59.28, which is above the current price, indicating bearish near-term pressure. The RSI (Relative Strength Index) reads 35.431, suggesting the stock is neutral with balanced momentum.

Money Flow Indicators: The Chaikin Money Flow (20-day) is 0.142, which is positive, indicating accumulation by institutional investors. Our AI-powered investment score rates IONS at 49.8/100 with a HOLD recommendation.

IONS (Ionis Pharmaceuticals, Inc. Common Stock) Indicators

Last updated Sep 11, 2026

Indicator Value
RSI(14) 35.431
CMF (20) 0.142
ROC (10) -13.167
ADX (14) 23.762
Indicator Value
MACD (12,26,9) -0.96
AROONOSC (14) -64.286
WILLAMS %R (14) -82.89
MFI (14) 24.459

IONS Candlestick Patterns

No validated candlestick patterns fired for IONS in the last 10 sessions — that's normal. Only the ~15 patterns with a backtested edge (out of 60 textbook patterns) are tracked here.

Ionis Pharmaceuticals, Inc. Common Stock is below both the 50 Day and 200 Day SMA which is considered Bearish.

IONS Moving Averages Analysis

IONS (Ionis Pharmaceuticals, Inc. Common Stock) Simple Moving Averages

Moving Averages are last updated Sep 11, 2026

Days MA
10 58.14
20 59.38
30 57.96
50 59.28
100 67.3
200 73.06

IONS Fundamental Analysis

P/E (Forward) 90.9091
P/E (Trailing) --
Market Cap ($) 9.2 billion
Earnings/Share ($) -3.48
Net Profit Margin (%) -0.6466
Dividend/Share ($) --
EPS Estimate Current Year ($) -2.7022
EPS Estimate Next Year ($) -1.1123
WallStreet Target Price ($) 84.23
Most Recent Quarter

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.