Upstream Bio (UPB) Stock: Buy, Sell, or Hold?
$3.20
-0.18 (-5.33%)
▼
5d:
-13.51%
30d:
-9.86%
90d:
-53.69%
QUANTITATIVE VERDICT
WAIT
LOW Confidence (45%)
Quality Score
44/100
Position
FAIR
30-Day Fair Range
$2.81 – $4.11
Position: FAIR
Forward P/E & Valuation
-1.1x
Next 12M consensus est.
Wall Street Target
$24.00
+650.0% upside
Options IV & Volume
HIGH Vol
HIGH volume confirmation
Support / Resistance
$2.97 / $3.84
Trend: Strong Downtrend
Executive Thesis & Bottom Line
Forward Earnings Fair Value & Price Prediction →
⏸️ WAIT FOR STABILIZATION: UPB is down 13.5% over the last 5 days. While fundamentals may be solid, catching a falling knife is risky. Wait for price to stabilize before entering.
Get Alerted When UPB Hits Your Target Price
Join 10,000+ traders who never miss a move
You're in! Check your email to confirm and set your target price.
100% Free
No spam, ever
Unsubscribe anytime
Interactive Price Chart (1 Month)
Loading chart...
Loading historical data...
In-depth Analysis How we analyze
Valuation Analysis: UPB is currently trading at $3.20, which is considered fair relative to its 30-day fair value range of $2.81 to $4.11.
Technical Outlook: Technically, UPB is in a strong downtrend. Immediate support is located at $2.97, while resistance sits at $3.84. Short-term momentum is weak, with the stock down 5.3% recently.
Market Sentiment: UPB scores 25/100 on our bottoming-setup gauge. Note this measures entry quality, not trend direction — a low score can mean the chart is extended after a strong run (don't chase) or still falling without stabilization; better entries typically come after a pullback toward the 20-day average. Wall Street analysts see significant upside, with an average price target of $24.00 (+650.0%). Current signals suggest waiting for a better entry point before initiating new positions.
Technical Outlook: Technically, UPB is in a strong downtrend. Immediate support is located at $2.97, while resistance sits at $3.84. Short-term momentum is weak, with the stock down 5.3% recently.
Market Sentiment: UPB scores 25/100 on our bottoming-setup gauge. Note this measures entry quality, not trend direction — a low score can mean the chart is extended after a strong run (don't chase) or still falling without stabilization; better entries typically come after a pullback toward the 20-day average. Wall Street analysts see significant upside, with an average price target of $24.00 (+650.0%). Current signals suggest waiting for a better entry point before initiating new positions.
Quick Decision Summary
Current Position
FAIR
Historical Trading Range
$2.81 -
$4.11
Company Quality Score
44/100
(HOLD)
Volume Confirmation
HIGH
Confidence Score
44.7%
Trading Range & Key Levels
30-Day Trading Range
$2.81 -
$4.11
Current vs Trading Range
FAIR
Support Level
$2.97
Resistance Level
$3.84
Current Trend
Strong Downtrend
Technical data as of
Nov 11, 2026
Quantitative Signal Breakdown
- NEUTRAL: Price in fair range
- BEARISH: Weak technical setup (25/100)
- BULLISH: High volume confirmation
- BEARISH: Downward momentum (-5.3%)
- BULLISH: Trading 650.0% below Wall St target ($24.00)
- WARNING: Composite score 44/100 in the bottom quintile — this cohort historically lags the market
Fundamental Context
Forward P/E (Next Year Est.)
-1.13
Wall Street Target
$24.00
(+650.0%)
Revenue Growth (YoY)
-17.5%
Share UPB Analysis
Share this live UPB analysis (with rich preview card) to Reddit, StockTwits, X, or embed the chart on your blog.
bloggers & journalists: you are free to use our charts with attribution.Reddit & Retail Trader Sentiment (UPB)
Bearish
1 Retail Mentions
StockTwits Volume
1 msgs
24h retail stream
Last Tracked
Nov 6, 2026
Daily AI digest
AI Retail Discussion Summary:
Top shareholder Fidelity sold over 50% of their shares in $UPB.
Key Retail Themes:
shareholder sentiment
selling pressure
Aggregated from r/wallstreetbets, r/stocks & StockTwits streams.
View All Trending Reddit & WSB Stocks →
Last updated: November 12, 2026 2:19 AM ET
Data refreshes hourly during market hours. Next update: 3:19 AM
Data refreshes hourly during market hours. Next update: 3:19 AM
🔥 Top Stocks Breaking Out Now
| Ticker | Score | Recommendation | Change % |
|---|
Technical Signals Check
Is UPB showing a specific setup today?
Insider Activity (6 Months)
0
Buys
0
Sells
0
Net
NEUTRAL
Top Rated Biotechnology Stocks
Top-rated stocks in Biotechnology by analyst ratings.
| Stock | Analyst Consensus | Analyst Target | Tradestie Score |
|---|---|---|---|
|
PRAX
Praxis Precision Medicin… |
STRONG BUY
21 analysts |
$650 | 38 SELL |
|
NAMS
NewAmsterdam Pharma Comp… |
STRONG BUY
16 analysts |
$50 | 44 HOLD |
|
IMUX
Immunic Inc |
STRONG BUY
13 analysts |
$43 | 51 HOLD |
|
ACAD
ACADIA Pharmaceuticals I… |
STRONG BUY
20 analysts |
$31 | 43 HOLD |
|
DYN
Dyne Therapeutics Inc |
STRONG BUY
17 analysts |
$34 | 39 SELL |
Explore More Analysis & Live Quant Tools
Part A: Deep-Dive UPB Research Pages
